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Hydration plays a crucial role in managing patients with elevated serum calcium levels, particularly in the prevention of kidney stones. Elevated calcium levels can lead to hypercalcemia, which can increase the risk of calcium-based kidney stones due to higher concentrations of calcium in the urine. When patients are well-hydrated, there is an increased urine volume, which helps dilute the concentration of calcium in the urine and decreases the likelihood of stone formation.

Additionally, adequate hydration promotes kidney function, allowing for more efficient clearance of excess calcium from the bloodstream. Since kidney stones can cause significant pain and complications, proper hydration is an essential preventive measure.

The other options, while relevant in some contexts, do not specifically address the primary role of hydration in the management of elevated serum calcium. For instance, while hydration may support recovery in general and help with fatigue, those aspects are secondary to its primary function of kidney stone prevention in this scenario. Mobilizing calcium from the bones is more related to other physiological processes and not directly influenced by hydration levels. Thus, the impact of hydration on preventing kidney stones stands out as the most significant aspect regarding elevated serum calcium levels.